Whilst the opiate receptor relies on G protein coupling for sign transduction, this receptor was discovered to make the most of arrestin activation for internalization of your receptor. Normally, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable enhancement in binding efficacy. This… Read More


Scientists have not long ago identified and succeeded in synthesizing conolidine, a all-natural compound that displays assure to be a powerful analgesic agent with a far more favorable protection profile. Although the specific system of action continues to be elusive, it really is at the moment postulated that conolidine might have quite a few biol… Read More